Author Archives: Alisha Amelia

How Do I Find Clinical Trials That Might Be Right for Me?

Most volunteers in clinical trials find out about them through their doctor, but you can also find clinical trials using other approaches.

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There are two main ways of finding information on clinical trials.

Clinical Trial Lists

This source will provide names and definitions of available clinical trials testing new treatments.

Along with descriptions, the list will also state patient eligibility criteria and contact information. Some organisations may provide services to help narrow the list for you according to your desired treatment.

Clinical Trial Matching Service

Several organisations have created computer-based systems that match patients to studies they could be eligible for. Clinical trial matching services are usually found online.

Services may differ in how they work. Some services will allow you to search for a clinical trial without registering on their website. Others will require you to register first, but the site will usually confirm that your details and information will remain confidential.

Certain details such as your patient information may be required, so the matching service can locate clinical trials you may be eligible for, which will save you the effort of searching and time wasted reading study descriptions that do not apply to you.

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You may also have the opportunity to sign up to a mailing list which will notify you when new studies are available.

Inclusion and Exclusion Criteria

All research trials have guidelines which dictate who can take part, depending on certain criteria. The factors that qualify you for a research trial are known as inclusion criteria, which could be the right age bracket and certain medical conditions or treatments.

Factors that will exclude you from a clinical trial are known as exclusion criteria. All research trials are approved by independent research ethics committees.

I’m Eligible – Is This Trial Right for Me?

Once you have found the right clinical trial, it is important to find out as much as you can before signing up. For paid research studies, enquire with companies such as trials4us.co.uk.

It is important to discuss the trial with someone involved, such as the clinical or principal investigator who is leading the trial. A research coordinator, usually a nurse, ensures protocol is adhered to and often provides a link between doctors and patients in the study.

FDA approves new leukaemia drug

The US Food and Drug Administration (FDA) has approved a new medication that can be used to treat Acute Myeloid Leukemia (AML).

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The drug, Enasidenib, was discovered by a research team consisting of global hematological scientists. It is bringing hope when it comes to the treatment of Acute Myeloid Leukemia (AML). This is a severe form of cancer in adults that is often incurable.

The Genetics of Acute Myeloid Leukemia

Humans have a gene called IDH2. In about 15 per cent of people with AML, this gene is defective. This leads to the production of 2-hydroxyglutarate (2-HG). 2-HG prevents bone marrow from forming mature blood cells. Instead, it produces immature cells that suppress the bone marrow, so the patient will have to receive frequent blood transfusions. In addition, the immature cells prevent the formation of white blood cells that help the body to fight infections, making patients susceptible to infections.

The treatment for AML has traditionally been chemotherapy. This novel drug, however, targets the IDH2 enzyme, reducing the production of 2-HG. This decreases the production of immature cells that cause AML.

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Phase 1 Clinical Trial

The Phase 1 Clinical Studies of Enasidenib was published in the Blood Journal. Cancer Research UK states that Phase 1 Clinical Studies help to determine if a treatment would be effective, the dose at which it is safe, and its side effects.

The clinical trials showed the novel drug was effective in 40 per cent of the 176 patients who had AML; 19 per cent of these people went into total remission. The patients recruited received fewer blood transfusions and developed few side effects.

The discovery of Enasidenib was important because other drugs had been ineffective in treating the participants of the trial.

The results produced by the trial and available research showed Enasidenib works. This led to the approval of the drug by the FDA. In performing clinical trials, experienced personnel including those at http://www.richmondpharmacology.com can help gain early approval of the Adaptive Phase 1 Clinical Studies by regulatory bodies.

The way forward

Enasidenib is not effective in all patients, perhaps due to other gene mutations. Scientists in Oxford are involved in a study to find the cause of resistance to Enasidenib. They will also establish if AML treatment would be more effective if the novel drug is combined with other forms of treatment.

Learn to Concentrate

The Effects of Different Kratom Strains

Kratom is a plant found in Southeast Asia and is renowned as an herbal remedy for various health diseases and problems. It grows in a number of countries including Malaysia, Thailand, Indonesia, Vietnam, Bali and Myanmar due to which there is a bit of variation in every strain. The chemical composition of these strains is quite varied due to which their effects can also vary. You have to know about each strain and the effects it has in order to use it for your treatment. Here are the most popular ones that are currently available in the market:

  • Red Vein Bali

This is a very sedating and relaxing Kratom strain. It is highly recommended for those people who wish to use Kratom for its role as an analgesic and sedative. You can find it in Indonesia and the areas surrounding it. Since it was first discovered in Bali, it has been named after it, but it grows in Indonesia as well and some surrounding regions too. There are numerous effects that have made it popular. First off, this strain can have a very positive effect on the human body because it contains a high quantity of alkaloids. There are over 20 alkaloids in red vein Bali and they enable it to relieve pain and have a mild sedation effect. It can also reduce stress and anxiety effectively.

  • Solid Gold Bali

Those who are looking for a fast acting strain will find solid gold Bali immensely useful. It can give you a solid boost in energy only 20 minutes after consuming it. People suffering from chronic pain will also find it helpful because it is very powerful and strong and takes effect quickly as opposed to other strains available.

  • Super Green Malay

If you are looking for a Kratom strain that can help you relax in the best possible way, Super Green Malay is your answer. It is known to have cognition-enhancing properties and is an ideal choice for people who want to concentrate better. With this strain, you will be able to increase mental energy, focus and endurance. It also has some mild analgesic effects, but this won’t allow it to make you lose focus or energy. The cells in this strain have thick cell walls, which means it doesn’t break down quickly and can have long lasting effects as a result.

  • Green Borneo

This is the best Borneo strain available because it combines the benefits of the two other strains; white and red. You can use it for alleviating pain associated with chronic conditions. It can have a very solid effect on your mood as well because it can elevate it to euphoric levels. You will also see improvements in concentration and reduction in anxiety and stress when you consume green Borneo strain.

  • Indonesian White Horn

If you are seeking stimulation, you cannot go wrong with the Indonesian White Horn. Its effects can be very strong and can actually wake you up and give you the endurance and energy needed to get through the day.

Tips for Caring for an Elderly Parent

One of the most rewarding and important things that an adult child can do is to take good care of their aging parents. Whether they are ill and in need of a great deal of care, or simply need a little bit of extra help to maintain their independence, there are many ways that you can help out. Although it can be easy to lose track of all of the things that need to be done, with a little planning, some preparation, and a good attitude, you can make sure that your parents live out their golden years with health and happiness.

Help Make Positive Lifestyle Changes

The best thing that you can do for your parents every day is to make sure that they are leading healthy lives. This means eating healthy food, exercising regularly, and avoiding bad habits that they may have taken up in their lives. Of course, you don’t have to follow a strict diet, work out every day, or avoid all of the pleasures of life. Just help your parents to plan and stick with a decent routine that involves some physical activity like swimming or walking, encourage eating fresh fruits and vegetables, and encourage them to get help to stop smoking or drinking excessively if necessary.

Get Them The Medical Care They Need

It’s essential that your elderly parents keep up with their medical needs and see their doctor regularly. If they need specialized care, help them find a respected professional that can make sure they’re getting all of the care that they need. For example, if you need to find a physicians group of South Florida, check out well-established and reliable groups like Tenet Florida Physician Services. Make sure that they are keeping their appointments and filling their prescriptions regularly, and encourage them to talk to their doctor quickly if any new symptoms or problems arise.

Stay in Touch

Finally, don’t forget how important it is to stay in regular contact with your parents. Even if you live far away, check in regularly to make sure that they sound alright and are doing well. Keep up your relationship and, if you have children, make sure that they get to see and talk to their grandchildren as much as possible. Sometimes, this kind of emotional connection is the most important thing you can do for their health.

Anxiety

Insomnia; Understanding its Causes, Symptoms and Treatments

You got into bed on time, but cannot sleep even after a few hours. Before you knew it, it was time to go to work and you haven’t slept a wink. Obviously, you were tired the entire day and could barely concentrate on whatever you were doing. The same thing happens the next night, and the next, and the next and so on. What is this? In one word; this is insomnia. It is perfectly normal for people to have a bout of insomnia from time to time, but if it becomes common, then it can be a major problem because it will take a toll on your mental and physical health as well as other aspects of your life.

The first step is to understand what causes insomnia. Let’s take a look:

Causes

  • Anxiety or stress
  • An uncomfortable sleeping environment or a change in it
  • Taking medicines that have insomnia as a side effect
  • Smoking cigarettes, drinking alcohol or coffee
  • Eating a heavy meal before going to bed
  • Exercising before bedtime
  • Hormonal imbalance
  • Chronic medical illnesses like asthma or kidney disease
  • Psychiatric issues such as PTSD or depression
  • Painful conditions like neuropathy, arthritis or acid reflux
  • Restless leg syndrome that causes twitching or cramping in the legs that wake you up or even obstructive sleep apnea that pauses your breathing

Once you know the causes of insomnia, you should be aware of its symptoms to identify it properly:

Symptoms

  • Not be able to fall asleep
  • Waking up during the night periodically
  • Feeling up irritable and tired during the day
  • Waking up earlier than needed and not feeling refreshed
  • Difficulty in concentrating

The doctor is able to find out the cause of your insomnia by asking you questions about your sleep environment and habits and by reviewing your symptoms. You may also be asked to keep a sleep diary if a cause is not immediately evident from your answers. When the cause is clear, a proper treatment can be prescribed.

Treatments

  • Relaxation therapy includes special techniques that help in relaxing the muscles and quieting the mind.
  • A program called sleep restriction may also be implemented, which will only permit you to sleep only a couple of hours initially and will then gradually increase your time as you begin to fall asleep quickly and without waking up.
  • Reconditioning is another method widely used, which involves teaching you to only associate your bed with sexual activity and sleeping. This way, you will only go to bed when you are sleepy and avoid daytime naps. In addition, you will keep distractions like your smartphone and TV out of the bedroom.
  • For the short term or for occasional use, doctors also prescribe medications such as Etizolam. You will find this particularly useful if you are also suffering from anxiety because this is an effective anti-anxiety remedy that calms you down and promotes healthy and quality sleep.

Follow these steps to help keep your child safe

You can’t always be around to keep your children safe, but you can teach them ways to look after themselves.

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Ban personalised items

If a stranger seems to know a child’s name, then the child is far more likely to think that they can trust them, so get rid of named lunchboxes, personalised bags and anything else that will give their identity away.

Have a code word

Have a code word that only you, trusted family and friends and your children know. They can then use this to check if someone really should be picking them up from school or to alert you to them feeling uncomfortable, if they phone you from a neighbour’s house, for example, even if that person has undergone a basic DBS check.

No body secrets

Make it a rule that children never keep secrets about body parts, even if they’ve been told to by somebody else. They should know to tell you immediately if someone has touched or spoken about parts of their body and have told them not to share their ‘secret’ with anyone else.

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Escape tips

Teach your children that if they think they are being followed by someone in a car, they should turn and run off in the opposite direction, meaning that the car will probably have to turn around before it can carry on in pursuit.

You should also ensure that they fully understand the concept of stranger danger and know that strangers don’t have to look ‘scruffy’ or ‘weird’ and could even be someone who passed a basic DBS check with flying colours. More tips on staying safe can be obtained on the NSPCC website at https://www.nspcc.org.uk/preventing-abuse/keeping-children-safe/staying-safe-away-from-home/.

Find a mum

Teach them to turn to a mother with children for help. Obviously, there is no guarantee that every mum is going to be suitable, but the odds are fairly good, even if she hasn’t been the subject of a basic DBS check.

Raise the alarm

Tell your children to make people around them aware that they are in danger by shouting out previously-discussed words and phrases like ‘help, leave me alone’ or ‘who are you?’.

Fight back

Make sure that your children know that they don’t need to remember their manners or do as they’re told if they feel in danger, even when dealing with an adult.

How to encourage your child to maintain good oral hygiene

Children are often reluctant to brush their teeth, but oral hygiene is such an important issue that you need to teach them how to care for their teeth from an early age.

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Start as soon as your baby’s teeth appear

Wipe new baby teeth gently with a piece of damp gauze or soft cloth after feeds. This will familiarise your little one with the idea that teeth need cleaning and make it easier to introduce a toothbrush later. Let children watch you and other family members flossing and brushing your teeth.

Make it fun

Special toothbrushes with your child’s favourite cartoon character can encourage them to brush their teeth. You can also get musical brushes or those that light up. Try letting your child choose his own toothbrush at the chemist or supermarket. One Dublin dentist has even composed a special teeth-cleaning song for children.

Choose pleasant-tasting toothpaste

Although considerations such as the amount of fluoride and cost are important, if your child does not like the taste of a toothpaste, he will be reluctant to brush his teeth. Choose a toothpaste that your child likes.

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Meet the dentist

Familiarising your children with the dentist early can mean that they are more cooperative later on. When you visit a practice such as https://cathedraldentalclinic.com/cosmetic-dentistry-cardiff/#main for a check-up, take your children so they can see it is not scary.

Teaching children how to brush their teeth at their early age may make cosmetic dentistry very easy and natural.

Flossing

Between the ages of around two to five, the teeth begin to close together; this is when you need to introduce flossing. Coloured flossers are more attractive to children than conventional floss.

The right diet

Many parents give their children snacks that they believe to be healthy throughout the day, but these can be responsible for tooth decay. According to the Express, fruit juices, dried fruit and yoghurts that are often seen as healthy snacks can cause tooth decay. It is how often the teeth are exposed to sugary food that poses a problem. Plain water and milk are better than juice, and snacks such as cheese and crunchy raw vegetables like carrot sticks are preferable.

Positive reinforcement

A rewards chart can motivate your children to brush their teeth. These can be downloaded from the internet and printed so they can record each time they brush their teeth and earn rewards at the end of the week.

Which Plastic Surgeon Is the Best?

Plastic surgery is truly an amazing thing. This type of surgery has the ability to remove unsightly scars and give women the shape they have always wanted. Plastic surgery can also remove stretch marks, moles, birthmarks and many other things to improve your appearance and confidence. There are many plastic surgeons in most cities. Now it will be up to you to take the next step and make an appointment with several plastic surgeons. Have them evaluate your problem and recommend the procedures you should have performed. Here are a few of the best methods of finding a terrific plastic surgeon.

1. Check sites that give reviews of plastic surgeons.

Review websites are a great way to see if a plastic surgeon really has a good track record or not. You would be smart to read as many reviews as possible in order for you to find out if a plastic surgeon is really very skilled. Stay away from the plastic surgeons who have many negative reviews written about them. There must be something wrong with a dentist if he gets an abundance of bad reviews.

2. Ask your friends and family members if they have ever got any plastic surgery performed.

You might need to find a facility that specializes in cosmetic surgery North Carolina. Therefore, this selection process can be a very tough one to go through. You would be wise to ask all of your friends and family members to find out if they ever had any plastic surgery performed. If they have, find out the specific nature of the procedure. What was the name of the surgeon they used?

3. Does the plastic surgeon charge a lot?

Surgical procedures will have varying prices associated with them. Some will cost much more money than others. You need to talk to many plastic surgeons to find out how much each one charges for their services. What types of insurance coverage does each dentist take? Some dental procedures are not covered by insurance because they are cosmetic. Therefore, it would be a very good idea to contact your insurance provider to find out exactly which types of dental procedures they will be willing to pay for. You can then figure out the financial burden that you will be expected to pay. Always remember that the cheapest plastic surgeon is not necessarily the best.

Lasagne five ways… and none of them include mince

A perfect summer’s day lunch or the ultimate comfort food for a cold winter’s evening; it is one of our favourite classic dishes.

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This wide, flat-shaped pasta is one of the oldest types and originated in Italy during the Middle Ages, with the first recorded lasagne recipe recorded in the 14th Century. The word ‘lasagne’ has an ancient origin, and comes from the Greek word laganon, meaning strips of flat pasta dough sheets.

So how has lasagne remained such a popular dish for so long? The pasta sheet, gooey cheese, distinctive sauce and meat is a delicious combination that is easy to make and can be extremely versatile.

To create truly tasty Italian dishes ensure you use the best ingredients and cookware.

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A dish that is constantly reinvented and reimagined with new ingredient combinations, why not reject meat in favour of colourful combinations of vegetables or salmon as a seafood alternative? There are plenty of online food recipes such as those found at http://food-tales.com/online-food-recipes/.

Here are five delectable variations on lasagne… and none include mince!

1 Lasagne with sage bechamel and pumpkin

Sacrificing meat does not mean sacrificing flavour, and this combination is proof! A delightful seasonal recipe of pumpkin and Swiss chard with a sage cream sauce and a blend of parmesan, ricotta and mozzarella cheeses. This dish makes a dazzling entrée at a dinner party.

2 Salmon and parmesan roll-up lasagne

Although a controversial combination, the pairing of cheese and fish can be incredibly tasty.

3 Parmesan chicken lasagne

Chicken is the perfect alternative to minced meat for a lasagne dish. A lighter option full of protein, a parmesan chicken lasagne oven baked with garlic is a stunning dinner dish. Make a garlic butter creamy sauce instead of béchamel and include peas for a truly tasty lasagne.

4 Lasagne soup

When you crave the comfort of lasagne on a winter evening, try making a warming soup with tomato, sausage, lasagne noodles and cheese. Perfect for any cold day, this dish requires one pot, perfect for a simple mid-week dinner.

5 Roasted vegetable lasagne

Take the opportunity to add extra vegetables into mealtimes and create a healthier lasagne dish with roasted vegetables such as aubergines, courgettes and peas. Add peppers and tomatoes for a tasty and colourful lasagne dish.

Sizzurp is the cough syrup drug that brings new anticipation among the teenager

Purple drink which contained an addictive element like codeine has become the second most consumed drug in the United States. We all know about Justin Bieber’s addiction to this highly consumed sizzurp, a home based drink prepared with ingredients like cough syrup, soda, and sweet candy was unveiled after the police have investigated the record in his residence in California. Like this Canadian star singer, millions of other young kids are also being exposed to falling into the drug networks by this fun type drug. In fact, Justin Bieber has decorated his skating rink with the help of graffiti. In which he was able to read double cup, a designating glass of sizzurp drinks with the usual codeine.

This drink is also known by the name of purple drank or lean drink that has the main ingredients codeine and promethazine from the cough syrup and mixed with some soft drinks such as sprite or mountain dew and with sweets candies like Jolly Rancher to give it its characteristic value of purple looks.

More Here: Purple Drank Sizzurp

The Ministry of Health department has already published a survey report in which they said that one of the key components for making this as an addictive new fashionable drug is cough syrups and it’s getting very popular among the young kids rapidly due to its easy accessibility.

Some medicines agency has already demanded to stop selling them without a prescription in the United States. Now they do not contain codeine, but they contain dextromethorphan, which is also an effective substance to take as an addictive drug among the teenage consumers. Recently the US Drug Enforcement Administration has estimated that 1 out of 10 teenagers have begun to uses cough medicine syrup as an alternate drug substance because of easy accessibility and their low price. Most of the pharmacies sell this cough syrup over the counter (many of the syrups don’t require any prescription) as a frequent home kits medication.

Purple drank has a component named Dextromethorphan or DXM which is known as the brother of heroin and this component directly come from cough syrups. They are sold in all pharmacies without any prescription and price is as low as less than 5 bucks. So if the dose required only 15 ml which is a recommended, they don’t care to take 360 (especially young kids). The worse part of it is they often mix this liquid with some alcohol. It’s better to know that soluble product in ethanol component can easily produce an initial state of hallucinations, euphoria, losing the sense of orientation and drive through unconsciousness.

It’s the time to aware and informed others about the serious health consequence of it. More on Purpledranksizzurp.com