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Anxiety, depression and self-abandonment

Do you have anxiety or depression? Find out the root cause of these painful feelings and what you can do about it. Most current feelings of anxiety and depression – apart from anxiety and depression that have physical or chemical causes – are caused by some form of self-neglect. Anxiety and depression are the way of your inner guidance to let you know that you are abandoning yourself. Most people want to believe that their anxiety or depression is being caused by the past, other people or events, but these are not the cause of the most current anxiety and depression. Continue reading

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facial hair

How to remove facial hair

Who wants to keep those annoying facial hair? Before removing them you have to make sure how that will impact in your body. Facial hair grows in different parts of our body. To remove them it depends on which part of the face the hair is on, there are several methods that can be used. Continue reading

What hazards do your cat’s fleas pose to your health?

Fleas are the scourge of animal lovers worldwide. Fleas live off of the blood of their host animal, causing intolerable and relentless itching. Animals that suffer allergic reactions to the bites require medical intervention. The fleas can cause even more serious health conditions since serious flea infestations can make the host animal anemic or infect them with parasitic worms. But fleas do not pose a health danger to just animals alone; fleas can cause illnesses in people too.

Cat fleas are carriers of the murine typhus disease. When a human is a bit by cat fleas that carries this disease, the person can then become infected with the disease. The fleas will defecate on the person as it feeds on their blood. If the person than scratches the bite and rubs the feces into the skin, the person can then become infected with the disease known as endemic typhus. Symptoms of the disease include fever, headaches, chills, and often a rash. Treatment of endemic typhus is administered by an antibiotic.

Cat fleas can also cause other health ailments in humans. Flea bites can cause a person to develop a rash known as fleabite dermatitis. This usually occurs when the person has an allergic reaction to the saliva in the flea bites. Fleas can also carry tapeworms that can be ingested by humans. Both illnesses are treatable but can cause discomfort to the person unlucky enough to be afflicted.

So now you know, fleas are not just a problem for the animals. Fleas carry diseases that are a hazard to humans as well. If your cat has fleas, it is important to treat immediately. The longer you delay treatment, the worse your flea infestation will become. Once the fleas begin to move into the environment, the people that reside in the infested habitat will be more likely to suffer flea bites. And the flea bites can lead to one of the conditions above.

Natural properties for dandruff free hair

Effective tips and natural properties for dandruff free hair

Do you still have dandruff no matter how much you wash your hair? Here we will tell you the reason, check out these tips to eliminate dandruff and follow our recommendations. Dandruff is a problem that we can all suffer at some point in our lives; it is an annoying condition that consists of excessive desquamation of the scalp cells. In this article, we give some tips and natural properties for dandruff free hair.

The skin frees frequently dead cells that are detached naturally or with the help of an exfoliation, the cells that make up the scalp are not the exception to this rule, however, when dandruff appears we are facing an increased detachment speed that can due to multiple causes.

Effective tips and natural properties for dandruff free hair

  1. Effective tips and tips to eliminate dandruff
  2. Treatments for dandruff
  3. Natural remedies for dandruff

Here we show some effective recommendations that you should know and tips to eliminate dandruff and show off your hair in its entire splendor.

1. Effective tips and tips to eliminate dandruff

To control dandruff it is necessary to know its origin, these can be:

  • Bad habits in hair care
  • Use of inappropriate products for your scalp
  • Stress
  • Oily skin

These causes can be controlled and eliminate dandruff from its origin. Bad habits can be avoided by adopting new ones, for this, you need at least 21 days of good healthy habits for washing and hair care.

It is demonstrated that this is the number of days that a person needs to adopt a good healthy habit.Healthy habits for washing



Hair products tend to accumulate on the scalp causing dandruff if you notice that a product causes you dandruff, change it to another or alternate its use with other products.

Stress is a condition that alters our entire body, for dandruff caused by stress you should only control the causes that lead to suffering from this condition and apply relaxation techniques frequently, such as mindfulness.

If you suffer from oily skin then it is likely that excess fat leads to the peeling of the skin.

A fatty scalp occurs when, paradoxically, we have dry skin; therefore it is necessary to nourish our scalp using products such as olive oil and avocado masks.

If your hair is oily, anti-dandruff products will only make your problem worse, since they tend to dry the scalp, which in turn stimulates the production of fat.Stress

2. Treatments for dandruff

If attacking dandruff from its origin does not work, then you must resort to the following methods:

Anti-dandruff shampoo for dandruff free hair

It is the most basic treatment for dandruff; these shampoos contain active ingredients such as:

  • Salicylic acid
  • Pitch
  • Ketoconazole
  • Zinc pyrithione
  • Selenium sulfide

So that its effect is the expected one it is necessary to wash the hair every day with the shampoo and let it act for 5 to 10 minutes while massaging the scalp with the tips of the fingers.

You should rinse the shampoo with plenty of water to avoid residues that irritate the skin and cause dandruff, itching or irritation. Use warm water; you should not use cold or hot water.

It is necessary that you alternate shampoos with various ingredients and active ingredients to prevent your skin from adapting to the components.

Use hydro alcoholic lotions after washing the hair to combat dandruff. Brush your hair every day and do not touch it with your hands, the grease and dirt of the same contribute to dandruff.Zinc pyrithione

Read the ingredients of your shampoo, if it contains lauryl sulfate and you use it frequently it will dry out your scalp causing more dandruff.

Eat foods rich in zinc; a deficit of this mineral can cause dandruff. The foods that you should consume are:

  • Pork
  • Nuts
  • Oysters
  • TurkeyNuts

3. Natural remedies for dandruff

You can complement all these tips to eliminate dandruff with natural remedies, such as the use of dandruff shampoos and other treatments.

If your shampoo only dries your hair and causes more dandruff, then it is necessary that you migrate to other types of products such as natural ones; if the problem persists you should consult a dermatologist to find a cure for your dandruff.

Lemon juice for dandruff free hair

Apply the pure lemon juice on the scalp, it will burn, but you should let it act for 20 to 25 minutes to take effect. Lemon is a natural astringent that will eliminate the causes of root dandruff. Then wash your hair with normal shampoo.Lemon juice for dandruff free hair

Olive oil for dandruff free hair

Place olive oil on your hair and massage with the tips of your fingers for about 10 minutes. Then wash your hair as you normally do.

If you need a quick remedy to dandruff for an important event, soak your scalp with olive oil, wrap it with a hair cover and leave on all night.

When you wake up wash your hair, you will notice that you do not have a gram of dandruff.

Egg yolks for dandruff free hair

Mix two egg yolks and apply them on the dry scalp. Cover with a hat and let it act for one hour.

Wash your hair by repeating the shampoo twice to leave the hair clean.Egg yolks for dandruff free hair

Fenugreek seeds for dandruff free hair

They are one of the most effective remedies against dandruff; you must grind a spoonful of these seeds and let them soak in two cups of water at night.

When washing the hair, apply this water at the end and let it dry.

Baby oil for dandruff free hair

As with olive oil, baby oil is used to combat dandruff. Massage a little of this oil on your scalp, wrap in a towel and leave on overnight.

Wash your hair with anti-dandruff shampoo when you wake up.Baby oil for dandruff free hair

Sodium bicarbonate for dandruff free hair

Instead of using shampoo you can use sodium bicarbonate, this product acts in various ways in the body and to eliminate dandruff is one of the best options. Moisten your hair and massage a tablespoon of baking soda on the scalp, let it act for a minute and rinse it.

This remedy will give results in two weeks when your scalp regains the ability to generate its natural oils.

Baking soda and lemon for dandruff free hair

Combining two natural remedies is also a good option; mix a tablespoon of baking soda with lemon juice.

Apply on the scalp and let it act for a few minutes. When you start itching, rinse your hair.Baking soda

Coconut oil for dandruff free hair

Like other oils that you can use, coconut oil is a good remedy for dandruff.

Wash your hair as you normally do, do not use conditioner and dry it.

Apply coconut oil to your scalp, not your hair. Massage and rinse your hair again, you should probably use shampoo.

Apply this treatment once a week until dandruff disappears.

Tea tree oil for dandruff free hair

Use a shampoo with tea tree oil, it is a natural antiseptic and helps eliminate dandruff. Use the shampoo and let it act for five minutes.

Use it every day until dandruff disappears.Tea tree oil for dandruff free hair

Mouthwash for dandruff free hair

It is a good option to prevent dandruff, after applying all the tips and effective recommendations to eliminate dandruff it is necessary to prevent its reappearance, for it uses mouth rinse once a month. Mix 1 part mouthwash with 9 water, and rinse your hair with the mixture when you finish washing. Do not rinse it and fix your hair as you normally do.

Dandruff is a problem with a solution; you just have to be constant with all the existing remedies to control it.

We hope you will like these tips and natural properties for dandruff free hair. We want your comments and suggestions to improve our ideas.

Tricks for men to make the shopping experience a pleasant moment

10 tricks for men to make the shopping experience a pleasant moment

Buying is an almost sacred ritual. Going from store to store, searching for the required garment, comparing prices, fabrics, models, and styles is an activity that requires time and dedication. It cannot be done lightly. Some people think that it is easy to buy: you enter the store of your choice, choose, test, and decide, pay and leave, there is no more. However, this activity goes much further. It requires patience, a good eye to choose the clothes and above all, good taste. In this article, we give you 10 tricks for men to make the shopping experience a pleasant moment.

It is not of another world, nor is it something that is impossible to realize. Buying can be a relaxing and even pleasant activity. There is no need to break your head or want to kill the seller, just learn a few simple steps that will make the shopping experience a pleasant and comforting moment.

10 steps to make the shopping experience a pleasant moment:

  • Be clear about what you are going to buy
  • Keep in mind what clothes interest you
  • Try on several garments
  • Go accompanied
  • Turn the store several times
  • Know your size
  • Be basic
  • Stay tuned for offers
  • Guide online
  • Do a store inspection

1. Be clear about what you are going to buy

Men are usually very specific. They know what they want and they go to the place where they sell it. Do not stop doing it, but look at several stores. If what you want is a white shirt, for example, visit at least three different stores, you may find the same with different details that will call your attention, the price may be different or the quality of workmanship. Do not stay only with the first garment. Dedicate time to the search.

Be clear about what you are going to buy            

2. Keep in mind what clothes interest you

This in order to buy only what is necessary. If your jeans stand out in your wardrobe, almost any shirt combines, but if you have shorts or sportswear, the shirt is not the best option. Try to buy the clothes you will wear most often for everything you keep in the closet.

3. Try on several garments

Maybe you want to buy a shirt and suddenly, you get a pair of jeans, a leather jacket or even a pair of shoes on the way. Make an analysis of what you like, what you require and if it suits you to buy both or just one. In the same way, consider the materials and prices.Try on several garments

4. Go accompanied to make your shopping experience a pleasant moment

Maybe, sharing the activity with someone else is the much better option for both, since you will not only know the tastes of another person, but it will help you to focus your own and while you have an opinion about the shirt you are going, your companion can suggest other models.Go accompanied to make your shopping experience a pleasant moment

5. Turn the store several times

Check what’s there. From the most basic garment to the most incredible eccentricities. Sometimes, the more you search the better deals you find. They are discounts on fabrics, prices, quality or sizes. That is, behind a dresser you may find the shirt you are looking for, but in a size that fits you better.

6. Know your size

Learn what the true build of your body is and then, choose the ideal size, which may be smaller or greater than you always use. Remember, anyway, try on the clothes you are about to buy. It does not matter if you have to return several sizes of jeans or if you take three sizes of the same garment to the tester. Remember that each store has an average of sizes that vary a bit. If you are or will be a frequent consumer, you should know what size you are in each store.

7. Be basic

If you do not like shopping, you should buy what best suits you not to return in a while: white shirts and some color prints, t-shirts, jeans, more formal pants, sneakers, miner’s boots. A pair of ties, a black suit and one of color (gray or brown), sports socks, socks, boxers, leather jacket and even accessories such as a cap or a watch. Do not buy all the same day, but create your own list of basics and analyze very well what you use most often and how you should combine it.Be basic

8. Stay tuned for offers

When summer ends, most stores put their clothes at half price or with a significant discount. Go to them and if you find a garment of your choice, do not hesitate to buy it. Make the account, it may be better for you to buy two or three different items on offer, one per month or each time you think you need it. In general, offers last longer in men’s clothing, since almost no boy enjoys shopping; few find out about offers and discounts.

9. Guide online

Check online catalogs to buy what you want without any problem. This guide serves to be able to go with the employees of the place and be very specific. This way you will not feel pressured by their suggestions or by not finding the garment of your preference.

10. Do a store inspection

This in order to know what you like or what place offers more products for you. Maybe the fashion store does not have everything you need, while the smallest, the one that has very few people entering through its doors, has a wider variety for you.Do a store inspection

Buying is an experience that is enjoyed and felt. Take your time to find the clothes that you like and that fit your body, learn from the experience of buying, is not a risky activity, or exclusive to women. We can all learn to buy a garment that fits the body and makes us look more attractive. Take a risk to go shopping.

We hope you will like these 10 tips to make the shopping experience a pleasant moment. We want your comments and suggestions to improve our ideas. Wish you a very happy new year!

8 Fundamental keys for a healthy family coexistence

8 Fundamental keys for a healthy family coexistence

Family coexistence is never easy and often difficult situations are generated that can be repeated frequently, and if they are not solved they can end up breaking the family bond. In this article, we will explain the 8 fundamental keys for a healthy family coexistence, to learn to overcome the inevitable crises and to also enjoy altogether of the successes of each one.

These keys are given below

  • First of all, talk
  • Establish moments of conviviality
  • Respect privacy
  • Share tasks
  • Know how to ask for forgiveness
  • Celebrate successes together
  • Never lose respect
  • Avoid arguments
  1. First of all, talk

The basis of all understanding is in communication, and problems that are not spoken, but are simply left there, unresolved, often accumulate and cause major conflicts later on.

If a family member has a problem, we should encourage them to share it, especially if it is a strictly family problem, to find solutions together.

But beware, that does not mean that we should not respect the emotions of each one when the problem is actually a private matter that wants to solve oneself.

  1. Establish moments of conviviality

Sometimes the work schedules are complicated and make the moments in common difficult, but you have to always look for ways to find them. Not only at meal times, but also to do activities, watch a movie, listen to music, dance, exercise, etc.

  1. Respect privacy

As important as looking for moments of coexistence knows how to respect the privacy of each member of the family. One of the issues that cause the most conflicts is that of not letting each person have their private space and their own way of doing things. Once some general guidelines are established, each one should have the freedom to do them in their own way. We must also respect that some have moments or days of more need for isolation.

  1. Share tasks

Carrying a family involves many tasks that children can learn from very young. According to age and availability, but everyone should be able to collaborate in domestic tasks, without having to receive any reward or reward for it. Yes, you can find ways for the little ones in the house to be fun, so that they get used to not seeing it as a burden.

  1. Know how to ask for forgiveness

How much it costs us to ask for forgiveness many times! Sometimes we know we have been wrong but asking for forgiveness is not easy, and yet it is essential for a healthy coexistence. The saying goes that to be wrong is human, but to rectify is wise, and although you have to overcome the pride, the truth is that the reward is a great joy on the part of the people involved. The one who asks for forgiveness, because it causes him satisfaction and takes away a burden from him, and the one who forgives, because he has the possibility of doing so.

  1. Celebrate successes together

Every success of a family member, even for something unimportant, is a joy for everyone. We should not miss the opportunity to celebrate every little achievement. It is not necessary to prepare a party, but you can prepare a special meal, surprise with a detail, or simply share the joy together. The happiness of good times will also give the strength to cope better with the bad. Listen to music,

  1. Never lose respect

Respect is fundamental in all families, especially the elderly and parents, but in fact, among all, there must be a respect. And respect is taught by example. You cannot ask for respect from the children if between the father and the mother is being continually lacking. Even if there is anger or arguments, disrespect should never be allowed.

  1. Avoid arguments

Although problems always arise, it is one thing to talk to try to solve them and quite another to discuss. Of course, we no longer refer to shouting discussions, which are very harmful to coexistence. Discussions affect all family members, even younger children, although we sometimes think that they do not understand what is happening. If we notice that we are nervous we take a while until we notice that we relax, and then we face the problem. Things never look so terrible the next day.

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How to be a more elegant woman with some simple tricks

How to be a more elegant woman with some simple tricks

Being an elegant woman goes beyond wearing clothing and accessories of luxury brands, is synonymous with good taste, attitude, education, and class. In this post, we will discuss how to be a more elegant woman with some simple tricks.

It is a lifestyle that only some women decide to adopt, but being elegant is not as complicated as it seems and we can all become one if we want to. Therefore, we leave you some tips to surprise everyone and become the most elegant woman you would like to be.

10 tricks to be an elegant woman

  • Improve your posture
  • Light makeup
  • Know yourself more
  • Avoid carelessness
  • Invest
  • Watch your mouth
  • Be more accurate
  • Find a balance
  • Leave more to the imagination
  • Do not shout the brand
  1. Improve your posture: It will not do any good if you look gorgeous if you’re bent or pulling your belly. Try to keep your back straight when you are standing, but also when you walk and you feel. It is important that your posture is natural and comfortable with it; otherwise, you will look fake instead of elegant.
  2. Light makeup: For example, if your eyes are dark or very flashy, choose a nude lipstick but if you want to paint your lips red, make up your eyes in a more natural way. An elegant woman does not need kilos of makeup to excel.
  3. Know yourself more: Identity which are the tones that go best with your skin tone and what are the clothes that favor your body, without looking vulgar. It is also important that you identify your personal style and that you be faithful. Avoid following trends, which do not go with you just because they are fashionable.
  4. Avoid carelessness: Dirty, wrinkled or old-looking clothing projects a bad image of you and is elegantly zero in a woman. The same applies to your hygiene and personal care, from your hair and your smell to your nails should look good.
  5. Invest: We recommend investing in items that will give a classy touch to any of your outfits, such as a good pair of stilettos or a bag that is easy to combine and that you can always use. A sophisticated perfume that goes with your personality is also a great investment.
  6. Watch your mouth: Avoid using profanity and shouting when speaking, the most elegant women stand out for their good education and kindness. In addition, they are usually educated and intelligent, so they always have an interesting topic of conversation. Light makeup
  7. Be more accurate: Make sure the clothes and shoes you wear are your sizes. Something that is too big or too tight will never look good and less elegant. You must also be wise to adapt to the weather and the occasion, respect the etiquette codes of the events you go to.
  8. Find a balance: You can adopt different tendencies, without abusing. For example, avoid using more than three different colors in your outfit and do not combine animal print with sequined garments or metallic colors. Your accessories should also be in balance with your look; when you resort to neutral-toned clothing it is better to wear flashy pieces but if your clothes are very heavy you should choose discreet accessories. This is the key to being a more elegant woman.
  9. Leave more to the imagination: Teaching too much skin is not sexy, it’s vulgar. The best thing is that you are more subtle. We suggest you use one neckline at a time, either on the back or chest. If you wear a tight blouse, it is best that your skirt is long and your pants baggy.
  10. Do not shout the brand: It is not necessary that we know who is the designer of each of the pieces you are using. In fact, elegant women tend to be more discreet and do not need to wear the most expensive clothes to highlight their class, because they know that elegance has to do with their good taste and not with their money.

How to help treat your sensitive teeth

Ouch! If this is your response when you drink or eat something cold, the likelihood is that you have sensitive teeth, but what causes sensitive teeth and how can you treat them? There are many reasons individuals can suffer anything from an occasional twinge to severe pain. If you have tried treating your teeth yourself for a few weeks without any improvement, your next step is to fix a dental appointment.

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Reasons for sensitive teeth include bleaching your teeth, gum disease, receding gums, lost tooth enamel due to too many acidic drinks and/or too much acidic food, grinding your teeth, gum disease, and brushing your teeth too hard or from side to side. Your dentist will be able to identify what is causing your sensitivity during an examination, so don’t worry if you can’t pinpoint the cause yourself.

Brushing your teeth

When it comes to brushing your teeth, dentists will always advise you to not only brush the biting, inner and outer surfaces of your teeth but also to concentrate on the spaces between your teeth. An article in the Telegraph has some great advice on the best way to make sure your teeth are not only cleaned properly but also on mouthwash and when to clean your teeth. Any professional working in general dentistry in Leicester will also be able to advise you.

Choose a brand of toothpaste made specially for people with sensitive teeth, making sure it contains flouride. You can dab these toothpastes directly onto the sensitive area to help manage the discomfort; however, be aware that it may take several days or weeks of regular use before they take effect.

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Tips for sensitive teeth

Your dentist will be able to give you the best advice for your situation, with experts such as sjrdental able to offer you personalised treatments to make avoiding cold drinks or food a thing of the past.

Every two or three months is the right time to change your toothbrush – unless, of course, it is worn, in which case do it straight away.

A night-time only mouthguard could be the answer to stopping you grinding your teeth, so please talk to your dentist if you know you grind your teeth.

Finally, arrange regular dental appointments and follow your dentist’s advice.

Want to keep fit while away? These exercises need no equipment

We work hard all year to maintain our health and fitness, so it is frustrating when a business or pleasure trip gets in the way.

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Once we’ve been away from our routine, it can be difficult to pick it up again. Thankfully, there are a series of really good exercises that don’t require any equipment at all, helping to keep us on track until we return home.

NYC-based personal trainer Albert Matheny talks about how different equipment-free exercises can be beneficial on BuzzFeed. These moves can revolutionise your work-outs.

Hotel rooms and self-catering apartments such as the Birmingham serviced apartments at no. 8 Waterloo Street apartments will provide you with plenty of space to train. All you will need is 20 minutes and a chair to easily stay in shape.

Warm up

A five-minute warm-up is essential, so begin with one minute of exercises such as jumping jacks, high knees, leg swings, arm swings, shoulder circles and core twists.

Arm Exercises

There are a series of arm exercises you can do without weights.

Push-ups are straightforward and can be done anywhere. Just make sure your hands are shoulder-width apart, your back is flat and your core is tight. Tricep dips are also quite simple to perform, so just grab a chair and lower yourself toward the floor until your elbows reach a 90-degree angle before raising yourself back up.

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Leg Exercises

Squats are another easily performed exercise. If you grab that chair again, you can have a go at the single leg stand. Sit with both feet on the floor, lift one leg, and by leaning forward, use your other leg and core to return to standing. To work your calves, try some heel raises.

Core Exercises

There are numerous core exercises you can do without the need for any bulky or expensive gym equipment. Both the plank and side plank will help to keep you strong while working out your lower back and obliques, so challenge yourself and see how long you can hold the position.

To feel the benefit of your in-room work-outs, it is recommended that you perform 12 repetitions of each exercise two or three times. This will keep you in shape, help you relax, and ward off that sluggish feeling when you finally return to your usual training routine.

How Do I Find Clinical Trials That Might Be Right for Me?

Most volunteers in clinical trials find out about them through their doctor, but you can also find clinical trials using other approaches.

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There are two main ways of finding information on clinical trials.

Clinical Trial Lists

This source will provide names and definitions of available clinical trials testing new treatments.

Along with descriptions, the list will also state patient eligibility criteria and contact information. Some organisations may provide services to help narrow the list for you according to your desired treatment.

Clinical Trial Matching Service

Several organisations have created computer-based systems that match patients to studies they could be eligible for. Clinical trial matching services are usually found online.

Services may differ in how they work. Some services will allow you to search for a clinical trial without registering on their website. Others will require you to register first, but the site will usually confirm that your details and information will remain confidential.

Certain details such as your patient information may be required, so the matching service can locate clinical trials you may be eligible for, which will save you the effort of searching and time wasted reading study descriptions that do not apply to you.

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You may also have the opportunity to sign up to a mailing list which will notify you when new studies are available.

Inclusion and Exclusion Criteria

All research trials have guidelines which dictate who can take part, depending on certain criteria. The factors that qualify you for a research trial are known as inclusion criteria, which could be the right age bracket and certain medical conditions or treatments.

Factors that will exclude you from a clinical trial are known as exclusion criteria. All research trials are approved by independent research ethics committees.

I’m Eligible – Is This Trial Right for Me?

Once you have found the right clinical trial, it is important to find out as much as you can before signing up. For paid research studies, enquire with companies such as trials4us.co.uk.

It is important to discuss the trial with someone involved, such as the clinical or principal investigator who is leading the trial. A research coordinator, usually a nurse, ensures protocol is adhered to and often provides a link between doctors and patients in the study.

FDA approves new leukaemia drug

The US Food and Drug Administration (FDA) has approved a new medication that can be used to treat Acute Myeloid Leukemia (AML).

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The drug, Enasidenib, was discovered by a research team consisting of global hematological scientists. It is bringing hope when it comes to the treatment of Acute Myeloid Leukemia (AML). This is a severe form of cancer in adults that is often incurable.

The Genetics of Acute Myeloid Leukemia

Humans have a gene called IDH2. In about 15 per cent of people with AML, this gene is defective. This leads to the production of 2-hydroxyglutarate (2-HG). 2-HG prevents bone marrow from forming mature blood cells. Instead, it produces immature cells that suppress the bone marrow, so the patient will have to receive frequent blood transfusions. In addition, the immature cells prevent the formation of white blood cells that help the body to fight infections, making patients susceptible to infections.

The treatment for AML has traditionally been chemotherapy. This novel drug, however, targets the IDH2 enzyme, reducing the production of 2-HG. This decreases the production of immature cells that cause AML.

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Phase 1 Clinical Trial

The Phase 1 Clinical Studies of Enasidenib was published in the Blood Journal. Cancer Research UK states that Phase 1 Clinical Studies help to determine if a treatment would be effective, the dose at which it is safe, and its side effects.

The clinical trials showed the novel drug was effective in 40 per cent of the 176 patients who had AML; 19 per cent of these people went into total remission. The patients recruited received fewer blood transfusions and developed few side effects.

The discovery of Enasidenib was important because other drugs had been ineffective in treating the participants of the trial.

The results produced by the trial and available research showed Enasidenib works. This led to the approval of the drug by the FDA. In performing clinical trials, experienced personnel including those at http://www.richmondpharmacology.com can help gain early approval of the Adaptive Phase 1 Clinical Studies by regulatory bodies.

The way forward

Enasidenib is not effective in all patients, perhaps due to other gene mutations. Scientists in Oxford are involved in a study to find the cause of resistance to Enasidenib. They will also establish if AML treatment would be more effective if the novel drug is combined with other forms of treatment.